Meta-awareness
Meta-awareness (PROSE: Who Laws the Lawyers?) one umbrella term for the ability of some individuals to perceive that what was real to them in their own universe was actually fiction on another level of reality.
Jenny Everywhere
Several instances of Jenny Everywhere have shown or hinted that they know they are fictional characters.
Medium awareness was a central plot point of the Crossing Over of Worlds tale, itself a subset of the Crossover Wars project, in which various web comic characters were enlightened about their natures. (COMIC: Jenny Everywhere and the Crossing Over Worlds)
One Jenny explicitly introduced herself as an open-source superhero, to the confusion of her companion. (COMIC: Jenny Everywhere in Sob Story)
The Jenny who was a classmate of U.R. Hip was followed around by an asterisk hovering above her head, which directed readers to the standard disclaimer; other individuals occasionally remarked on the asterisk. (COMIC: The Asterisk Knows, et al.) She was also able to receive fan-mail from a dimension where her and I.M. Hip's adventures were a webcomic. (COMIC: Road to Nowhere)
One Jenny never addressed the fourth wall, but arrived and departed from the dimensions she visited by interacting with the world as a comic — opening panels of said comic like doorways and stepping through. (COMIC: By the Book)
Another Jenny, seen above, shifted into an empty white void and concluded that an empty and featureless universe meant the author must be asleep. (COMIC: Jenny Everywhere in Insert Comic Here)
Yet another Jenny not only got told she was fictional but quarreled with her writer Sizemore. (PROSE: Paperback Writer)
The Jenny of the Infinity Apartment once demonstrated that she was aware of her adventures coming in the form of six-panel comic strips and of the passage of time as measured in panels. Thuban shared this awareness. Jenny even commented upon the creator experimenting with new art styles. (COMIC: Infinity Apartment)
The SCP Foundation briefly interacted with a Jenny Everywhere who warned them she could only stick around as long as it made for an interesting story. (PROSE: SCP-JEv)
The Jenny Everywhere of the collapsed cosmos expressed awareness of her world being shaped by fictional narrative logic during her initial journey with Glendalf, although at the time she was in a state of reality she had entered through a book. (PROSE: The Hermetic Garbage of Jenny Everywhere)
One Jenny was so aware of her fictional nature that she edited entries on the Jenny Everywhere wiki. (PROSE: The Wiki Adventures of Lord Grallyx)
One Jenny once displayed a level of meta-awareness, promoting Gevity™ to the audience. This was depicted in a comic by Cookieboy 2005 in another universe. (COMIC: Jenny Says: Drink Gevity™!)
Others
Jenny's friend Lex hinted at this, as he seemed aware that his adventures with Jenny Everywhere had an audience and that this audience's taste affected their fates to some extent. (COMIC: Damn Fine Hostile Takeover)
Fellback was an antagonist who claimed granting Jenny web comic awareness was a matter of "...giving you choice! Relieving you of your fate!" The same Jenny later encountered her artist, who was naturally aware of his nature. (COMIC: Jenny Everywhere and the Crossing Over Worlds)
Herbie Popnecker openly told Jenny that their appearance had "met our obligation to the webcomic." They then departed, with Jenny telling others, "If I stay too long in one place, I'm likely to end up as part of the regular cast!" (COMIC: Meanwhile...)
Sizemore was a cruel writer who messed around with Jenny as one of his characters. (PROSE: Paperback Writer)
Thuban, one of the Jenny from the Infinity Apartment's neighbours and companions, was aware of his adventures taking the form of comic strips with limited numbers of panels somehow, much as Jenny herself.
The canonical powers of Zed Hudson, a young superhero in Universe Gemini, included “intermittent” fourth wall awareness — which mystified his friend Jenny. (COMIC: Zed Vs. The Superpowers)
Lord Grallyx was temporarily aware of his fictional nature on April Fool’s Day 2022 when it became the basis of an adventure. (PROSE: The Wiki Adventures of Lord Grallyx)
When Jenny Over-There angrily demanded that Jenny Nowhere go over her background before she started to lay out her vengeance monologue, she added that “worldbuilding allusions to a vast unseen backstory [were] all very well in moderation, but —” only to be interrupted by Nowhere herself, who chided her: “Leave the Fourth Wall alone, Red. Now is not the time or the place to weaken the structure of reality just for the hell of it”. (PROSE: Family Business) The Man in Grey, her boss, was said to have the highest level of meta-awareness out of the regular M.F.S. staff. (PROSE: Who Laws the Lawyers?)
Behind the scenes
In her original Cameo Comic series (and later in other titles), Scale was presented as a webcomic character created with fourth wall awareness and the ability to visit other comics.