Alexander the Great's conquest of Persia
From Jenny Everywhere Wiki
In Reality Z-25 31-H, according to Nula, Alexander the Great's conquest of Persia was motivated as much by Alexander's desire to claim the Philosopher's Stone as anything else. Though he was successful in claiming the gem, he never got to use it, as he died shortly after; the Stone then passed to Ptolemy of Egypt. (COMIC: Nula! Naked and Alone!)