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In some universes, the term of rune described a magical sigil which could hold a magical effect.
Ezri had a rune tattooed on her right cheek. Though symbolic of her status as the Marked One, chosen hero of prophecy in her home universe, its actual power was fairly minor; she used it to keep her hair black with purple ends, whereas it naturally grew blond. Ezri used the same design on her armour. (COMIC: Infinity Apartment)
In the Prime Universe, sometimes-magical Rune Stones were associated with Norse Mythology. (PROSE: The Winter Quests)