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Eight to One, later rebranded as 8:1, is a webcomic, also comprising at least one animated cartoon, created by Brian Duffy.
The comic focuses on the sitcom-esque misadventures of three very different residents of a nameless American city (the antisocial artist Charles, the solitary writer Mary Anne Atwood and the more sociable and sincere hitherto-country girl Lori Helen Newman. One of its earliest strips, COMIC: Eight to One Guest Starring Jenny Everywhere, the Shifter, featured a two-panel guest appearance by an incarnation of Jenny Everywhere.