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In the Prime Universe, M. Holmes (PROSE: Wanted for Questioning) was the brother of Sherlock Holmes.
He one of the guests at the Christmas dinner organised in 1895 at 221B Baker Street by Doctor Watson. Also invited were Sexton Blake, Mrs Hudson, Inspector Lestrade and Jenny Everywhere. (PROSE: The Time of the Toymaker)
“M. Holmes” would later be included in a list of Jenny's “known associates” across her incarnations on a Wanted poster put out by a large conglomerate of security organisations. (PROSE: Wanted for Questioning)
Behind the scenes
Mycroft Holmes was a character introduced by Arthur Conan Doyle himself to his Sherlock Holmes series, being defined as Sherlock's even more perceptive, but less proactive, older brother. Doyle depicted Mycroft as a unique “all-purpose government advisor”, discreetly dispensing his advice as needed to any department, high or low; later reimaginings have often moved Mycroft away from this generalised hypercompetent bureaucrat to an advisor to, or even the Victorian head of, the British secret services.